Selected Publications

Roffman, JL. Reaffirming Core Scientific Values in Psychiatry Research. Harvard Review of Psychiatry. 2019 September; doi:10.1097/HRP.0000000000000231

Eryilmaz H, Dowling KF, Huntington FC, et al. Association of Prenatal Exposure to Population-Wide Folic Acid Fortification With Altered Cerebral Cortex Maturation in Youths. JAMA Psychiatry. Published online July 03, 2018. doi:10.1001/jamapsychiatry.2018.1381

Roffman JL. Neuroprotective effects of prenatal folic acid supplementation: Why timing matters. JAMA Psychiatry. 2018 May; doi:10.1001/jamapsychiatry.2018.0378

Cummings D,* Dowling KF,* Silverstein NJ, Tanner AS, Eryilmaz H, Smoller JW, Roffman JL. A cross-sectional study of dietary and genetic predictors of blood folate levels in healthy young adults. Nutrients. 2017 Sept; 9(9):994

Eryilmaz H, Rodriguez-Thompson A, Tanner AS, Giegold M, Huntington FC, Roffman JL. Neural determinants of human goal-directed vs. habitual action control and their relation to trait motivation. Scientific Reports. 2017 Jul; 7, doi:10.1038/s41598-017-06284-y

Roffman JL, Petruzzi LJ, Tanner AS, Brown HE, Eryilmaz H, Ho NF, Giegold M, Silverstein NJ, Bottiglieri T, Manoach DS, Smoller JW, Henderson DC, Goff DC. Biochemical, physiological and clinical effects of L-methylfolate in schizophrenia: A randomized controlled trial. Molecular Psychiatry. 2017 Mar; doi: 10.1038/mp.2017.41

Roffman JL, Tanner AS, Eryilmaz H, Rodriguez-Thompson A, Silverstein NJ, Ho NF, Nitenson, AZ, Chonde DB, Greve DN, Abi-Dargham A, Buckner RL, Manoach DM, Rosen BR, Hooker JM, Catana C. Dopamine D1 Signaling Organizes Network Dynamics Underlying Working Memory. Science Advances. 2016 Jun; 2(6):e1501672

Eryilmaz, H, Tanner, AS, Ho, NF, Nitenson, AZ, Silverstein, NJ, Petruzzi, LJ, Goff, DC, Manoach, DS, Roffman, JL. Disrupted Working Memory Circuitry in Schizophrenia: Disentangling fMRI Markers of Core Pathology vs Other Aspects of Impaired Performance. Neuropsychopharmacology. 2016 May 11; ePub ahead of print. doi: 10.1038/npp.2016.55.

Holmes, AJ, Hollinshead, MO, Roffman, JL, Smoller, JW, Bucker, RL. Individual differences in cognitive control circuit anatomy link sensation seeking, impulsivity, and substance use. J Neuroscience. 2016 Apr 6;36(14):4038-49

Brain Genomics Superstruct Project initial data release with structural, functional, and behavioral measures. Holmes AJ, Hollinshead MO, O’Keefe TM, Petrov VI, Fariello GR, Wald LL, Fischl B, Rosen BR, Mair RW, Roffman JL, Smoller JW, Buckner RL. Sci Data. 2015 Jul 7;2:150031. doi: 10.1038/sdata.2015.31. eCollection 2015.

Roffman JL, Lamberti JS, Achtyes E, Macklin EA, Galendez GC, Raeke LH, Silverstein NJ, Smoller JW, Hill M, Goff DC. Randomized multicenter investigation of folate plus vitamin B12 supplementation in schizophrenia. JAMA Psychiatry. 2013 May; 70(5):481-9.

Roffman JL, Weiss AP, Purcell S, Caffalette CA, Freudenreich O, Henderson DC, Bottiglieri T, Wong DH, Halsted CH, Goff DC. Contribution of methylenetetrahydrofolate reductase (MTHFR) polymorphisms to negative symptoms in schizophrenia. Biol Psychiatry. 2008 Jan 1; 63(1):42-8.

Roffman JL, Brohawn DG, Nitenson AZ, Macklin EA, Smoller JW, Goff DC. Genetic variation throughout the folate metabolic pathway influences negative symptom severity in schizophrenia. Schizophr Bull. 2013 Mar; 39(2):330-8.

Brown HE, Roffman JL. Vitamin supplementation in the treatment of schizophrenia. CNS Drugs. 2014 Jul; 28(7):611-22.

Roffman JL, Nitenson AZ, Agam Y, Isom M, Friedman JS, Dyckman KA, Brohawn DG, Smoller JW, Goff DC, Manoach DS. A hypomethylating variant of MTHFR, 677C>T, blunts the neural response to errors in patients with schizophrenia and healthy individuals. PLoS One. 2011; 6(9):e25253.

Roffman JL, Weiss AP, Deckersbach T, Freudenreich O, Henderson DC, Wong DH, Halsted CH, Goff DC. 2008. Interactive Effects of COMT Val108/158Met and MTHFR C677T on Executive Function in Schizophrenia. Am J Med Genet Part B147B:990–995.

Roffman JL, Brohawn DG, Friedman JS, Dyckman KA, Thakkar KN, Agam Y, Vangel MG, Goff DC, Manoach DS. MTHFR 677C>T effects on anterior cingulate structure and function during response monitoring in schizophrenia: a preliminary study. Brain Imaging Behav. 2011 Mar; 5(1):65-75.

Roffman JL, Weiss AP, Deckersbach T, Freudenreich O, Henderson DC, Purcell S, Wong DH, Halsted CH, Goff DC. Effects of the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism on executive function in schizophrenia. Schizophr Res. 2007 May; 92(1-3):181-8.